Generated by All in One SEO v4.9.10, this is an llms.txt file, used by LLMs to index the site. # LEADS Longitudinal Early-Onset Alzheimer's Disease Study ## Sitemaps - [XML Sitemap](https://leads-study.medicine.iu.edu/sitemap.xml): Contains all public & indexable URLs for this website. ## Pages - [Home](https://leads-study.medicine.iu.edu/) - The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is an observational study that will enroll and follow 500 cognitively impaired participants and 100 cognitively normal participants ages 40-64 years at approximately 15 sites in the United States. - [Lectures & Webinars](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/) - [Ask the Researchers: Your Questions About Current Research](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2026-family-meeting/ask-the-researchers-your-questions-about-current-research/) - [Family Keynote - Afternoon Session](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2026-family-meeting/family-keynote-afternoon-session/) - [Family Keynote - Morning Session](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2026-family-meeting/family-keynote-morning-session/) - [Lifestyle, Brian Health, & Risk Reduction: What We Know and What You Can Do](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2026-family-meeting/lifestyle-brian-health-risk-reduction-what-we-know-and-what-you-can-do/) - [Advocacy in Action: Care, Community, & Change](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2026-family-meeting/advocacy-in-action-care-community-change/) - [Get Connected with the Alzheimer's Association](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2026-family-meeting/get-connected-with-the-alzheimers-association/) - [Understanding Brain Donation: Questions, Experiences, & Impact](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2026-family-meeting/understanding-brain-donation-questions-experiences-impact/) - [Current Advances in Younger-Onset Dementia Research & Future Directions](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2026-family-meeting/current-advances-in-younger-onset-dementia-research-future-directions/) - [Welcome Remarks](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2026-family-meeting/welcome-remarks/) - [2026 Family Meeting](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/) - [LEADS Data Request Application](https://leads-study.medicine.iu.edu/researchers/leads-data-request-application/) - [LEADS Executive Committee](https://leads-study.medicine.iu.edu/leads-executive-committee/) - [Benefits of Enrolling](https://leads-study.medicine.iu.edu/referring-clinicians/benefits-of-enrolling/) - [Study Visits](https://leads-study.medicine.iu.edu/participants/study-visits/) - [Referring Clinicians](https://leads-study.medicine.iu.edu/referring-clinicians/) - [LEADS Publications](https://leads-study.medicine.iu.edu/about/leads-publications/) - [About the Study](https://leads-study.medicine.iu.edu/about/) - [In the News](https://leads-study.medicine.iu.edu/about/in-the-news/) - [How to Enroll](https://leads-study.medicine.iu.edu/participants/how-to-enroll/) - [Family Keynote](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-fall-family-meeting/family-keynote/) - [Closing Remarks](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-fall-family-meeting/closing-remarks/) - [Current Therapeutic Updates](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-fall-family-meeting/current-therapeutic-updates/) - [Resource Session](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-fall-family-meeting/resource-session/) - [Get Connected with the Alzheimer's Association](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-fall-family-meeting/get-connected-with-the-alzheimers-association/) - [LEADS & iLEADS Updates](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-fall-family-meeting/leads-ileads-updates/) - [What's Next for LEADS?](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-fall-family-meeting/whats-next-for-leads/) - [LEADS Panel Discussion](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-fall-family-meeting/leads-panel-discussion/) - [Current Therapeutic Landscape Discussion](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-fall-family-meeting/current-therapeutic-landscape-discussion/) - [Opening Remarks](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-fall-family-meeting/opening-remarks/) - [2024 Fall Family Meeting](/about/leads-lectures-webinars/) - [Researchers](https://leads-study.medicine.iu.edu/researchers/) - [LEADS Publication Committee](https://leads-study.medicine.iu.edu/leads-publication-committee/) - [LEADS Data Sharing Committee](https://leads-study.medicine.iu.edu/researchers/data-sharing-committee/) - [Primary Aims](https://leads-study.medicine.iu.edu/about/primary-aims/) - [Social Worker Resources](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/social-worker-resources/) - [Early Onset Alzheimer's Disease (EOAD) Signature of Atrophy](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/early-onset-alzheimers-disease-eoad-signature-of-atrophy/) - [Genetics in LEADS](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/genetics-in-leads/) - [The Importance of Neuropathology](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/the-importance-of-neuropathology/) - [Day One - Closing Remarks](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/day-one-closing-remarks/) - [Day One - Opening Remarks](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/day-one-opening-remarks/) - [Emerging Treatments, Challenges & Opportunities](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/emerging-treatments-challenges-opportunities/) - [Day Two - Open Remarks](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/day-two-open-remarks/) - [Lorenzo's House](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/lorenzos-house/) - [Imaging Biomarkers](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/imaging-biomarkers/) - [Fluid Biomarkers](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/fluid-biomarkers/) - [Day Two - Family Keynote](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/day-two-family-keynote/) - [Elder Law & Estate Planning Resources](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/elder-law-estate-planning-resources/) - [The BEYONDD Project](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/the-beyondd-project/) - [LEADS Study Overview](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/leads-study-overview/) - [Get Connected with the Alzheimer's Association](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/get-connected-with-the-alzheimers-association/) - [Speech Pathology Resources](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/speech-pathology-resources/) - [Neuropsychology & Psychology Resources](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/neuropsychology-psychology-resources/) - [Resources for Enrolling in Clinical Trials](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/resources-for-enrolling-in-clinical-trials/) - [Day Two - Closing Remarks](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/day-two-closing-remarks/) - [Day One - Family Keynote](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2024-family-meeting/day-one-family-keynote/) - [2024 Family Meeting](/about/leads-lectures-webinars/) - [2021 Family Meeting](/about/leads-lectures-webinars/) - [Publications Submission](https://leads-study.medicine.iu.edu/researchers/publications-application/) - [Day Two Closing Remarks](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2022-family-meeting/day-two-closing-remarks/) - [Overview of Medical & Care Resources Following a Diagnosis](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2022-family-meeting/overview-of-medical-care-resources-following-a-diagnosis/) - [Communications & Considerations When Communicating with Research Participants](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2022-family-meeting/communications-considerations-when-communicating-with-research-participants/) - [Day Two Keynote](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2022-family-meeting/day-two-keynote/) - [Day One Closing Remarks](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2022-family-meeting/day-one-closing-remarks/) - [Overview of Diagnostics & Biomarkers in LEADS](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2022-family-meeting/overview-of-diagnostics-biomarkers-in-leads/) - [Importance of Neuropathology & Brain Donation](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2022-family-meeting/importance-of-neuropathology-brain-donation/) - [Social Workers Resources](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2022-family-meeting/social-workers-resources/) - [Day One Opening Remarks](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2022-family-meeting/day-one-opening-remarks/) - [Treatment Updates & Perspectives](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2022-family-meeting/treatment-updates-perspectives/) - [Day Two Opening Remarks](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2022-family-meeting/day-two-opening-remarks/) - [LEADS Study Update](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2022-family-meeting/leads-study-update/) - [Learnings from Imaging, Blood, Cerebrospinal Fluid & Genetics](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2022-family-meeting/learnings-from-imaging-blood-cerebrospinal-fluid-genetics/) - [Brain & Behavioral Changes](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2022-family-meeting/brain-behavioral-changes/) - [2022 Family Meeting](/about/leads-lectures-webinars/) - [Support Services & Educational Materials](https://leads-study.medicine.iu.edu/participants/support-groups/) - [Panel Session: Aducanumab Approval and the Dementia Treatment Pipeline: Considerations for Dementia in the Younger Person](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2021-family-meeting/panel-session-aducanumab-approval-and-the-dementia-treatment-pipeline-considerations-for-dementia-in-the-younger-person/) - [Understanding Biomarkers – Imaging, Blood, Cerebrospinal Fluid and Genetics](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2021-family-meeting/understanding-biomarkers-imaging-blood-cerebrospinal-fluid-and-genetics/) - [Alzheimer's Association Panel: Identifying & Accessing Support Groups, Other Resources, and Getting Engaged with Advocacy](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2021-family-meeting/alzheimers-association-panel-identifying-and-accessing-support-groups-other-resources-and-getting-engaged-with-advocacy/) - [Practical Considerations When Living with Early Onset Cognitive Impairment: Conversations with Attorney Pamela Greenfield](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2021-family-meeting/practical-considerations-when-living-with-early-onset-cognitive-impairment-conversations-with-attorney-pamela-greenfield/) - [Patient Perspective on the Importance of Receiving an Early Diagnosis](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2021-family-meeting/patient-perspective-on-the-importance-of-receiving-an-early-diagnosis/) - [Understanding Brain and Behavioral Changes Related to Cognitive Impairment – Including Alzheimer’s, Frontotemporal Dementia, Primary Progressive Aphasia and More](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2021-family-meeting/understanding-brain-and-behavioral-changes-related-to-cognitive-impairment-including-alzheimers-frontotemporal-dementia-primary-progressive-aphasia-and-more/) - [Opening Keynote LEADS: Study Goals & Future Directions](https://leads-study.medicine.iu.edu/about/leads-lectures-webinars/2021-family-meeting/opening-keynote-leads-study-goals-future-directions/) - [About This Study](/about/) - [Benefits from Enrolling](/referring-clinicians/benefits-of-enrolling/) - [Amyloid & Tau PETS in Sporadic Early-Onset Alzheimer's Disease: Preliminary Results from LEADS](https://leads-study.medicine.iu.edu/amyloid-tau-pets-in-sporadic-early-onset-alzheimers-disease-preliminary-results-from-leads/) - [MRI Measures of Neurodegeneration in the LEADS Cohort](https://leads-study.medicine.iu.edu/mri-measures-of-neurodegeneration-in-the-leads-cohort/) - [Examing Early-Onset & Late-Onset Alzheimer's Disease (EOAD) to Understand the Neuropathological Substract of Typical and Atypical AD](https://leads-study.medicine.iu.edu/examing-early-onset-late-onset-alzheimers-disease-eoad-to-understand-the-neuropathological-substract-of-typical-and-atypical-ad/) - [AAIC Study Design & Clinical Characteristics of the LEADS Cohort](https://leads-study.medicine.iu.edu/aaic-study-design-clinical-characteristics-of-the-leads-cohort/) - [Support Groups](/participants/support-groups/) - [How to Refer](/participants/how-to-enroll/) - [Donate](https://leads-study.medicine.iu.edu/donate/) - [Study Leadership](https://leads-study.medicine.iu.edu/about/study-leadership/) - [How to Enroll](/participants/how-to-enroll/) - [Enrollment Criteria](https://leads-study.medicine.iu.edu/referring-clinicians/enrollment-criteria/) - [Goals of LEADS](https://leads-study.medicine.iu.edu/referring-clinicians/goals-of-leads/) - [Who Can Sign Up](https://leads-study.medicine.iu.edu/participants/who-can-sign-up/) - [Participants](https://leads-study.medicine.iu.edu/participants/) ## Locations - [Northwestern University](https://leads-study.medicine.iu.edu/location/northwestern-university/) - [University of California, Los Angeles](https://leads-study.medicine.iu.edu/location/university-of-california-los-angeles/) - [Emory University School of Medicine](https://leads-study.medicine.iu.edu/location/emory-university-school-of-medicine/) - [Butler Hospital](https://leads-study.medicine.iu.edu/location/butler-hospital/) - [Indiana University School of Medicine](https://leads-study.medicine.iu.edu/location/indiana-university-school-of-medicine/) - [Banner Sun Health Research Institute](https://leads-study.medicine.iu.edu/location/banner-sun-health-research-institute/) - [Stanford University](https://leads-study.medicine.iu.edu/location/stanford-university/) - [Georgetown University](https://leads-study.medicine.iu.edu/location/georgetown-university/) - [Wein Center of Clinical Research](https://leads-study.medicine.iu.edu/location/wein-center-of-clinical-research/) - [Washington University, St. Louis](https://leads-study.medicine.iu.edu/location/washington-university-st-louis/) - [Mayo Clinic, Jacksonville](https://leads-study.medicine.iu.edu/location/mayo-clinic-jacksonville/) - [University of California, San Francisco](https://leads-study.medicine.iu.edu/location/university-of-california-san-francisco/) - [Massachusetts General Hospital / Harvard Medical School](https://leads-study.medicine.iu.edu/location/massachusetts-general-hospital/) - [Columbia University](https://leads-study.medicine.iu.edu/location/columbia-university/) - [Houston Methodist Hospital](https://leads-study.medicine.iu.edu/location/houston-methodist-hospital/) - [Johns Hopkins University](https://leads-study.medicine.iu.edu/location/johns-hopkins-university/) - [Mayo Clinic, Rochester](https://leads-study.medicine.iu.edu/location/mayo-clinic-rochester/) - [University of Pennsylvania](https://leads-study.medicine.iu.edu/location/university-of-pennsylvania/) ## Notification bars - [NIH Mandate Message](https://leads-study.medicine.iu.edu/wphash_ntf_bar/nih-mandate-message/) ## Categories - [University](https://leads-study.medicine.iu.edu/?category=university) - [Hospital](https://leads-study.medicine.iu.edu/?category=hospital) ## Departments - [Principal Investigators](https://leads-study.medicine.iu.edu/departments/principal-investigators/) - [Other Co-Investigators](https://leads-study.medicine.iu.edu/departments/co-investigators/) - [Site Principal Investigators](https://leads-study.medicine.iu.edu/departments/site-investigators/) - [Executive Committee](https://leads-study.medicine.iu.edu/departments/executive-committee/) - [Data Sharing Committee](https://leads-study.medicine.iu.edu/departments/data-sharing-committee/) - [Publication Committee](https://leads-study.medicine.iu.edu/departments/publication-committee/)